Home / ICD-10-CM / Chapter 21: Factors influencing health status and contact with health services (Z00-Z99) / Genetic carrier and genetic susceptibility to disease (Z14-Z15)

Z15.06: Genetic susceptibility to malignant neoplasm of digestive system

ICD-10-CM code Z15.06

New code ยท FY2026

Not billable: this is a header. Use one of the more specific codes below.

  • New code, effective October 1, 2025 (FY2026).

Code breakdown

Z15.06

  1. Z15CategoryGenetic susceptibility to disease
  2. 0Character 4Genetic susceptibility to malignant neoplasm
  3. 6Character 5Genetic susceptibility to malignant neoplasm of digestive system

Coding notes

Code first (from Z15.0)

  • , if applicable, any current malignant neoplasm (C00-C75, C81-C96)

Use additional code (from Z15.0)

  • code, if applicable, for any personal history of malignant neoplasm (Z85.-)

Includes (from Z15)

  • confirmed abnormal gene

Excludes1 (from Z15)

  • chromosomal anomalies (Q90-Q99)

Use additional code (from Z15)

  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Codes under Z15.06

  • Z15.060 Genetic susceptibility to colorectal cancer
  • Z15.068 Genetic susceptibility to other malignant neoplasm of digestive system

Check this code

All FY2026 ICD-10-CM changes

ICD-10-CM codes and descriptions are from the CMS and NCHS code files. Coverage is from the CMS Medicare Coverage Database billing and coding articles.