E78.010: Homozygous familial hypercholesterolemia [HoFH]

New code · FY2026

Billable: use this code on claims.

• New code, effective October 1, 2025 (FY2026).

Code breakdown

Coding notes

Excludes1 (from E78)

• sphingolipidosis (E75.0-E75.3)

Medicare coverage

E78.010 is listed as a covered diagnosis in 19 Medicare billing and coding articles:

• A54543 Therapeutic Apheresis for Familial Hypercholesterolemia
• A56289 Billing and Coding: Therapeutic Apheresis for Familial Hypercholesterolemia
• A56416 Billing and Coding: Assays for Vitamins and Metabolic Function
• A56422 Billing and Coding: Bariatric Surgical Management of Morbid Obesity
• A56774 Billing and Coding: Ophthalmic Angiography (Fluorescein and Indocyanine Green)
• A56943 Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment
• A57037 Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment
• A57145 Billing and Coding: Surgical Management of Morbid Obesity
• A57183 Billing and Coding: Cardiovascular Stress Testing, Including Exercise and/or Pharmacological Stress and Stress Echocardiography
• A57326 Billing and Coding: Electrocardiograms

…and 9 more. Check the coverage tool for your CPT code.

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All FY2026 ICD-10-CM changes

ICD-10-CM codes and descriptions are from the CMS and NCHS code files. Coverage is from the CMS Medicare Coverage Database billing and coding articles.